John F Lyons Selected Research

4- (2,6- dichlorobenzoylamino)- 1H- pyrazole- 3- carboxylic acid piperidin-4-ylamide

1/2011	Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.
4/2010	AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples.
2/2009	Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John F Lyons Research Topics

Disease

13	Neoplasms (Cancer) 10/2021 - 01/2003
3	Melanoma (Melanoma, Malignant) 01/2018 - 12/2014
2	Leukemia 09/2010 - 04/2010
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2016
1	Injection Site Reaction 01/2016
1	Fatigue 01/2016
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2016
1	Multiple Myeloma 01/2016
1	Nausea 01/2016
1	Prostatic Neoplasms (Prostate Cancer) 01/2016
1	Spasm (Spasms) 01/2016
1	Vomiting 01/2016
1	Neutropenia 01/2015
1	Anemia 01/2015
1	Thrombocytopenia (Thrombopenia) 01/2015
1	Pleurisy (Pleuritis) 01/2011
1	Inflammation (Inflammations) 01/2011
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 07/2010
1	Glioblastoma (Glioblastoma Multiforme) 05/2010
1	B-Cell Leukemia (Leukemia, B Cell) 04/2010
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/2010
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 04/2010
1	Colonic Neoplasms (Colon Cancer) 02/2009
1	Ovarian Neoplasms (Ovarian Cancer) 01/2003
1	Breast Neoplasms (Breast Cancer) 01/2003
1	Neoplasm Metastasis (Metastasis) 01/2003

Drug/Important Bio-Agent (IBA)

4	(2,4- dihydroxy- 5- isopropylphenyl)- (5- (4- methylpiperazin- 1- ylmethyl)- 1,3- dihydroisoindol- 2- yl)methanoneIBA 10/2016 - 12/2014
3	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2017 - 04/2010
3	1- cyclopropyl- 3- (3- (5- morpholin- 4- ylmethyl- 1H- benzoimidazol- 2- yl)- 1H- pyrazol- 4- yl)ureaIBA 01/2016 - 07/2010
3	Aurora KinasesIBA 01/2016 - 07/2010
3	Phosphotransferases (Kinase)IBA 12/2014 - 01/2003
3	4- (2,6- dichlorobenzoylamino)- 1H- pyrazole- 3- carboxylic acid piperidin-4-ylamideIBA 01/2011 - 02/2009
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2018 - 12/2014
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2003
2	Tyrosine Kinase InhibitorsIBA 10/2016 - 09/2010
2	Pharmaceutical PreparationsIBA 01/2015 - 01/2011
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 07/2012 - 05/2010
1	ASTX029IBA 10/2021
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2021
1	ASTX-660IBA 01/2018
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 01/2018
1	PeptidomimeticsIBA 01/2018
1	CrizotinibIBA 10/2016
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2016
1	Hormones (Hormone)IBA 01/2016
1	AndrogensIBA 01/2016
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	RNA (Ribonucleic Acid)IBA 01/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	Aurora Kinase AIBA 01/2015
1	VemurafenibIBA 12/2014
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2012
1	AT13148IBA 07/2012
1	rho-Associated KinasesIBA 07/2012
1	CaspasesIBA 01/2011
1	OvalbuminIBA 01/2011
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 01/2011
1	Imatinib Mesylate (Gleevec)FDA Link 09/2010
1	Threonine (L-Threonine)FDA Link 09/2010
1	Isoleucine (L-Isoleucine)FDA Link 09/2010
1	Janus KinasesIBA 07/2010
1	Adenosine Triphosphate (ATP)IBA 05/2010
1	Ribosomal Proteins (Ribosomal Protein)IBA 05/2010
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 05/2010
1	Glycogen Synthase Kinase 3 betaIBA 05/2010
1	AT 7867IBA 05/2010
1	RNA Polymerase II (RNA Polymerase B)IBA 04/2010
1	Biological ProductsIBA 02/2009
1	Growth Factor ReceptorsIBA 12/2003
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2003
1	CollagenIBA 01/2003
1	TensinsIBA 01/2003
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2003
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2003
1	IntegrinsIBA 01/2003
1	human AKT2 proteinIBA 01/2003
1	Complementary DNA (cDNA)IBA 01/2003
1	WortmanninIBA 01/2003

Therapy/Procedure

2	Therapeutics 01/2016 - 05/2010